正常房水引流阻力主要来自于小梁、近管结缔组织和Schlemm管内壁细胞。细胞骨架肌动蛋白在调节细胞形态的稳定性、细胞与细胞、细胞与细胞基质间的附着连接方面起着重要作用。肌动蛋白药物能够引起小梁细胞细胞骨架的改变。蛋白激酶抑制剂、肌动蛋白降解剂等几类肌动蛋白药物均可作用于小梁细胞细胞骨架,影响房水引流,降低眼压,说明肌动蛋白药物可能成为一种有用的抗青光眼治疗药物。就肌动蛋白药物降眼压作用及其作用机制进行综述。 Normal aqueous humor drainage resistance comes mainly from trabecular, proximal connective tissue and Schlemm’s inner lining cells. Cytoskeletal actin plays an important role in the regulation of the stability of the cell morphology, the attachment of cells to cells, and the attachment of cells to the cell matrix. Actin drugs can cause trabecular cell cytoskeletal changes. Protein kinase inhibitors, actin degradation and other types of actin drugs can act on the trabecular meshwork cells, affecting aqueous drainage and reduce intraocular pressure, indicating that actinomycin may become a useful anti-glaucoma treatment drug. The action of actin agonist on intraocular pressure and its mechanism were reviewed.