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目的探讨颅内肿瘤的危险因素和保护因素。方法采用成组设计病例对照研究方法,对264例原发性颅内肿瘤患者和273例对照进行问卷调查,应用非条件Logistic回归模型推断暴露因素与颅内肿瘤的关系。结果单因素和多因素Logistic回归分析结果表明,源于配偶的被动吸烟、源于同事的被动吸烟、职业性接触汽(柴)油和经常接触农药可增加患颅内肿瘤的危险性,其OR值及95%CI分别为1.777(1.103,2.861)、1.911(1.095,3.334)、4.298(1.008,18.314)和1.728(1.000,3.049)。饮酒和啤酒酒精摄入量<9mL/d可降低患颅内肿瘤的危险性,其OR值及95%CI分别为0.297(0.108,0.821)和0.216(0.046,1.024)。结论颅内肿瘤的危险因素为源于配偶及同事的被动吸烟、职业性接触汽(柴)油和经常接触农药;保护因素为饮酒和啤酒酒精摄入量<9mL/d。
Objective To explore the risk factors and protective factors of intracranial tumors. Methods A group case-control study was conducted to investigate the relationship between exposure factors and intracranial tumors in 264 patients with primary intracranial tumors and 273 controls by non-conditional Logistic regression model. Results The results of univariate and multivariate Logistic regression analysis showed that passive smoking from spouse, passive smoking from colleagues, occupational exposure to gasoline and frequent exposure to pesticides increased the risk of intracranial tumors. OR Values and 95% CIs were 1.777 (1.103, 2.861), 1.911 (1.095, 3.334), 4.298 (1.008, 18.314) and 1.728 (1.000, 3.049), respectively. Alcohol intake and alcohol intake of beer <9 mL / d reduced the risk of intracranial tumors with OR values and 95% CIs of 0.297 (0.108, 0.821) and 0.216 (0.046, 1.024), respectively. Conclusion The risk factors for intracranial tumors are passive smoking from spouses and co-workers, occupational exposure to steam (diesel) oil and frequent exposure to pesticides. The protective factors are alcohol consumption and beer alcohol consumption <9 mL / d.