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目的:探讨二甲双胍联合克罗米芬治疗多囊卵巢综合征合并不孕患者的疗效。方法:将收治的多囊卵巢综合征合并不孕患者96例随机分为观察组和对照组各48例,观察组接受二甲双胍联合克罗米芬治疗,对照组仅接受克罗米芬治疗。结果:观察组体质指数(BMI)、空腹胰岛素(FINS)、促黄体生成素(LH)、LH/促卵泡刺激素(LH/FSH)、睾酮(T)在治疗后显著降低,治疗前后比较差异有统计学意义(P<0.05);而FSH、雌二醇(E2)治疗前后相比差异无统计学意义(P>0.05)。对照组BMI、FINS、LH、LH/FSH、T、FSH、E2治疗前后相比差异无统计学意义(P>0.05)。治疗后观察组BMI、FINS、LH、LH/FSH、T显著低于对照组,差异有统计学意义(P<0.05);两组患者的FSH、E2相比差异无统计学意义(P>0.05)。治疗后观察组的排卵率、妊娠率显著高于对照组,差异有统计学意义(P<0.05)。结论:二甲双胍联合克罗米芬可提高多囊卵巢综合征患者对胰岛素的敏感性,并降低其LH、T等激素水平,提高患者的排卵率与妊娠率。
Objective: To investigate the efficacy of metformin combined with clomiphene in patients with polycystic ovary syndrome complicated by infertility. Methods: Ninety-six patients with polycystic ovary syndrome complicated with infertility were randomly divided into observation group and control group, 48 cases in each group. The observation group received metformin combined with clomiphene and the control group received clomiphene alone. Results: The body mass index (BMI), fasting insulin (FINS), luteinizing hormone (LH), LH / FSH and testosterone (T) in the observation group decreased significantly after treatment (P <0.05). There was no significant difference between FSH and estradiol before and after treatment (P> 0.05). There was no significant difference in BMI, FINS, LH, LH / FSH, T, FSH and E2 between before and after treatment in control group (P> 0.05). After treatment, the levels of BMI, FINS, LH, LH / FSH and T in the observation group were significantly lower than those in the control group (P <0.05). There was no significant difference in FSH and E2 between the two groups ). After treatment, the ovulation rate and pregnancy rate in the observation group were significantly higher than those in the control group (P <0.05). Conclusion: Metformin combined with clomiphene may increase the insulin sensitivity in patients with PCOS and reduce the levels of LH and T and improve the ovulation rate and pregnancy rate in patients with PCOS.