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目的探讨子痫前期发病危险因素,为疾病的预防和治疗提供依据。方法选择武义县妇幼保健院收治的子痫前期患者84例为观察组,另选择同期分娩的正常孕妇145例为对照组,自制调查问卷调查所有入选者的一般资料和可能的影响因子,将影响因子纳入Logistic回归模型进行单因素筛选和多因素分析。结果单因素非条件Logistic回归分析共筛选出孕妇年龄、高血压史、糖尿病或肾病史、孕前BMI、高血压家族史、孕期牙周疾病或尿路感染、初产妇、子痫前期史及自然流产史共9个子痫前期发病可能的危险因素(P<0.1);多因素Logistic回归分析显示,孕前BMI、糖尿病或肾病史、高血压史及自然流产史是子痫前期发病的独立危险因素(P<0.05)。结论子痫前期发病是由多种因素引起,应该加强对孕前BMI过高、有糖尿病或肾病史、高血压史及自然流产史等孕妇的孕前保健和孕期保健。
Objective To explore the risk factors of preeclampsia and provide the basis for the prevention and treatment of the disease. Methods Eighty-eight patients with preeclampsia treated by Wuyi MCH Hospital were selected as the observation group. Another 145 pregnant women with normal delivery were selected as the control group. The general information and possible influencing factors of all the participants in the self-made questionnaire will be affected Factors into the Logistic regression model for single factor screening and multivariate analysis. Results Univariate non-conditional Logistic regression analysis screened a total of pregnant women age, history of hypertension, history of diabetes or kidney disease, pre-pregnancy BMI, family history of hypertension, periodontal disease during pregnancy or urinary tract infection, primipara, preeclampsia and spontaneous abortion (P <0.1). Multivariate Logistic regression analysis showed that pre-pregnancy BMI, history of diabetes or nephropathy, history of hypertension and history of spontaneous abortion were independent risk factors for preeclampsia (P < <0.05). Conclusions The incidence of preeclampsia is caused by many factors. It is necessary to strengthen preconception and prenatal care for pregnant women with high pre-pregnancy BMI, history of diabetes mellitus or nephropathy, history of hypertension and history of spontaneous abortion.