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目的:探讨人乳头瘤病毒(human papilloma virus,HPV)21种基因型分型检测及其临床意义。方法:对我院门诊及住院因阴道不适症状就诊的1 636位女性进行HPV基因分型检测,比较不同基因型与临床疾病的特点。结果:本组资料中总的HPV感染率为28.0%(458/1636),检测出19种基因型,高危型最常见的类型为HPV16、58、52、53,低危型最常见的类型为HPV-81CP(8304)、HPV6;随着宫颈病变程度的升高,其HPV感染率呈趋势性增加;HPV感染有年龄集中趋势,30~49岁组感染比例最高,占51.3%,但各年龄段感染占该年龄段总就诊人数比例无明显差异;HPV感染各民族间分布未见明显差异。结论:HPV亚型感染与宫颈病变的不同程度关系密切,为宫颈癌的筛查、防治提供初步理论依据。
Objective: To investigate the genotyping and clinical significance of 21 human papilloma virus (HPV) genotypes. Methods: HPV genotyping was performed on 1 636 women in our outpatient clinics and inpatients with vaginal complaints. The characteristics of different genotypes and clinical diseases were compared. Results: The total HPV infection rate in this group was 28.0% (458/1636). Nineteen genotypes were detected. The most common types of high risk type were HPV16,58,52,53. The most common types of low risk type were HPV-81CP (8304), HPV6; With the increase of cervical lesions, the trend of HPV infection showed a trend; HPV infection has the tendency of age concentration, the highest infection rate is 30-49 years old, accounting for 51.3%, but all ages Sections of infection accounted for the total number of attendants in this age group no significant difference; HPV infection among the various ethnic groups showed no significant difference. Conclusion: HPV subtype infection is closely related to different degree of cervical lesions, providing a preliminary theoretical basis for screening and prevention of cervical cancer.