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目的 :研究肺癌患者体液免疫指标的变化及其与 CEA的关系。方法 :用自动生化分析仪和放免法定量测定 80例肺癌患者的血清球蛋白、Ig G、Ig A、Ig M及补体 3(C3)、补体 (C4)的量 ,设肺部良性疾病肺炎和正常人两组为对照组 ,运用 SPSS软件进行统计。结果 :肺癌组的球蛋白、Ig G、Ig A比肺炎和正常人明显升高 (P<0 .0 5 ) ,C3则比正常人降低 (P<0 .0 5 ) ,Ig M、C4两组差异无显著性 (P>0 .0 5 ) ,CEA阳性和 CEA阴性肺癌患者免疫球蛋白、补体差异均无显著性 (P>0 .0 5 ) ,肺癌患者的血清 CEA与 Ig A呈显著正相关 (P<0 .0 1)。结论 :肺癌患者的体液免疫功能增强。
Objective: To study the changes of humoral immunity in patients with lung cancer and its relationship with CEA. Methods: The quantities of serum globulin, Ig G, Ig A, Ig M, complement 3 (C3) and complement (C4) in 80 patients with lung cancer were determined by automatic biochemical analyzer and radioimmunoassay. Normal two groups as the control group, using SPSS software for statistics. Results: The levels of globulin, Ig G and Ig A in lung cancer group were significantly higher than those in pneumonia and normal subjects (P <0.05), C3 was lower than that in normal people (P <0.05), Ig M and C4 There was no significant difference between the two groups (P> 0.05). There was no significant difference in the immunoglobulin and complement levels between CEA positive and CEA negative lung cancer patients (P> 0.05), and the serum CEA and IgA were significantly higher in patients with lung cancer Positive correlation (P <0.01). Conclusion: The humoral immune function of patients with lung cancer is enhanced.