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目的研究常规溶栓联合氯吡格雷治疗急性ST段抬高心肌梗死患者的疗效和安全性。方法随机选择2005年1月至2007年12月于栾川县人民医院住院的急性ST段抬高心肌梗死发病6h以内患者90例,其中联合氯吡格雷治疗者(氯吡格雷组)48例,未联合氯吡格雷者(对照组)42例。观察两组主要疗效和安全性指标。结果氯吡格雷组较对照组具有较高的血管再通率(分别为68.8%、50.0%,P<0.05),主要不良心脏事件发生率降低(分别为4.2%、14.3%,P<0.05),出血发生率与对照组比较差异无统计学意义(分别为8.3%、9.5%,P>0.05)。结论溶栓联合氯吡格雷治疗急性ST段抬高心肌梗死患者是安全有效的。
Objective To study the efficacy and safety of conventional thrombolysis and clopidogrel in the treatment of patients with acute ST-segment elevation myocardial infarction. Methods A total of 90 patients with acute ST-segment elevation myocardial infarction (MI) admitted to Luanchuan People’s Hospital from January 2005 to December 2007 were randomly selected. Among them, 48 patients were treated with clopidogrel (clopidogrel) 42 patients without clopidogrel (control group). Two groups were observed the main efficacy and safety indicators. Results The clopidogrel group had a higher rate of recanalization (68.8% vs 50.0%, P <0.05, respectively) and the incidence of major adverse cardiac events (4.2% and 14.3%, P <0.05, respectively) The incidence of hemorrhage was no significant difference compared with the control group (8.3%, 9.5%, P> 0.05). Conclusion Thrombolysis and clopidogrel are safe and effective in the treatment of patients with acute ST-segment elevation myocardial infarction.