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目的观察消旋卡多曲颗粒联合双歧杆菌三联胶囊治疗小儿轮状病毒性腹泻的临床疗效。方法选取定西市临洮县人民医院门诊收治的轮状病毒感染的急性腹泻患儿99例,随机分为三组:对照组(A组);双歧杆菌组(B组)在常规对症治疗的基础上给予双歧杆菌三联胶囊治疗;联合治疗组(C组)除给予双歧杆菌三联胶囊外,再给予消旋卡多曲颗粒。每组各33例。观察各组患儿腹泻症状改善时间及临床疗效。结果 B组和C组患儿呕吐停止时间、大便性状恢复正常时间和大便次数恢复正常时间、病毒转阴时间均短于A组(P<0.01),且B组与C组比较差异有统计学意义(P<0.05);三组患儿治疗后第3天、第5天、第7天病毒转阴率经比较差异有统计学意义(P<0.01);A组、B组和C组治疗有效率分别为78.8%、90.9%、100.0%,三组比较差异有统计学意义(χ~2=1.33,P<0.01)。结论通过常规对症治疗相比,消旋卡多曲颗粒联合双歧杆菌三连胶囊治疗婴幼儿轮状病毒性腹泻,能明显改善症状,缩短腹泻总病程。
Objective To observe the clinical efficacy of racecadotril granules combined with Bifidobacterium triple capsules in the treatment of pediatric rotavirus diarrhea. Methods Ninety-nine children with rotavirus-infected acute diarrhea admitted to Outpatient Clinic of Linyi County People’s Hospital of Dingxi City were randomly divided into three groups: control group (group A), Bifidobacterium group (group B) on the basis of routine symptomatic treatment Bifidobacterium triple capsules on treatment; combination therapy group (C group) in addition to triple Bifidobacterium capsule, and then given racecadotril particles. 33 cases in each group. To observe the diarrhea symptoms in each group to improve the time and clinical efficacy. Results The stopping time of vomiting, the normal time of recovering stool and the normal time of stool frequency and the time of virus negative conversion in group B and group C were shorter than those in group A (P <0.01), and there was statistical difference between group B and group C (P0.05) .After 3 days, 5 days and 7 days after treatment, the viral negative conversion rates of the three groups of children were significantly different (P0.01) .A group, B group and C group The effective rates were 78.8%, 90.9% and 100.0%, respectively. The differences between the three groups were statistically significant (χ ~ 2 = 1.33, P <0.01). Conclusion Compared with routine symptomatic treatment, racecadotril granules combined with Bifidobacterium Sanlian capsule in the treatment of infantile rotavirus diarrhea can significantly improve the symptoms and shorten the total duration of diarrhea.