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目的:分析我院碳青霉烯类抗生素用药频度(DDDs)与鲍曼不动杆菌对其耐药率的相关性,为临床合理用药提供依据。方法:采用K-B纸片扩散法测定抗菌药物敏感性,SPSS16.0软件进行数据分析;采用世界卫生组织推荐的限定日剂量(DDD)法分析常用抗菌药物的DDDs。结果:我院2011年4个季度碳青霉烯类抗生素的总DDDs逐季度减少,第4季度比第1季度下降9.74%,其中同期亚胺培南、帕尼培南分别下降了73.91%和95.22%,美罗培南的DDDs无明显变化;而鲍曼不动杆菌对碳青霉烯类抗生素的耐药率同期下降33.6%。结论:鲍曼不动杆菌的耐药率与碳青霉烯类抗生素总DDDs呈正相关(r=0.996,P<0.05),与亚胺培南、帕尼培南DDDs呈正相关(r分别为0.947、0.895,P均<0.05),与美罗培南DDDs无显著相关(r=-0.485,P>0.05)。
Objective: To analyze the correlation between the frequency of carbapenem antibiotics (DDDs) and the Acinetobacter baumannii resistance rate in our hospital and provide the basis for clinical rational drug use. Methods: K-B disk diffusion method was used to determine the antimicrobial susceptibility. SPSS16.0 software was used to analyze the data. DDDs of commonly used antimicrobial agents were analyzed by the DDD method recommended by the World Health Organization. Results: The total DDDs of carbapenem antibiotics in our hospital decreased quarter by quarter in quarter 2011, down 9.74% from the first quarter in the fourth quarter of 2011, of which, the rates of imipenem and panipenem decreased by 73.91% and 95.22%, no obvious change of meropenem DDDs; Acinetobacter baumannii carbapenem antibiotic resistance rate decreased by 33.6% over the same period. Conclusion: The drug resistance rate of Acinetobacter baumannii is positively correlated with total DDDs of carbapenems (r = 0.996, P <0.05), and is positively correlated with DDDs of imipenem and panipenem (r = 0.947 , 0.895, P <0.05), but no significant correlation with meropenem DDDs (r = -0.485, P> 0.05).