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目的探讨碱基错配修复基因hMSH2IVS12-6T>C多态性与江苏宜兴人群胃癌易感性之间的关系。方法采用分子流行病学病例对照研究方法,以552例胃癌患者和592例年龄(±5岁)、性别相匹配的非胃癌患者(对照组)作为研究对象,用TaqMan MGB(minor grove binder)探针对hMSH2IVS12-6T>C多态性进行基因分型,分析不同基因型与胃癌发生风险的关联性,通过分层分析探讨年龄、性别、吸烟及饮酒等因素对罹患胃癌的影响。结果与hMSH2IVS12-6TT基因型相比,TC和CC基因型均与胃癌发生风险无显著关联性(P=0.882和P=0.569)。合并突变基因型TC+CC并不显著降低胃癌的发生风险(调整OR=0.96,95%CI=0.75~1.23,P=0.756)。分层分析结果显示吸烟、饮酒、性别、年龄等因素与胃癌的发生风险亦无显著关联性。结论 hMSH2IVS12-6T>C多态性与江苏宜兴人群胃癌发生风险无显著关联。
Objective To investigate the relationship between the base mismatch repair gene hMSH2IVS12-6T> C polymorphism and susceptibility to gastric cancer in Yixing, Jiangsu Province. Methods Using molecular epidemiological case-control study, 552 gastric cancer patients and 592 age-matched (± 5 years) and non-gastric cancer patients (control group) The genotypes of hMSH2IVS12-6T> C polymorphism were analyzed. The association between different genotypes and risk of gastric cancer was analyzed. The effects of age, gender, smoking and alcohol consumption on gastric cancer were analyzed by stratified analysis. Results Compared with the hMSH2IVS12-6TT genotype, TC and CC genotypes had no significant correlation with the risk of gastric cancer (P = 0.882 and P = 0.569). The combined genotype of TC + CC did not significantly reduce the risk of gastric cancer (adjusted OR = 0.96, 95% CI = 0.75-1.23, P = 0.756). Stratified analysis showed no significant association between smoking, alcohol drinking, sex, age and other factors and the risk of gastric cancer. Conclusion There is no significant correlation between the hMSH2IVS12-6T> C polymorphism and the risk of gastric cancer in Yixing, Jiangsu Province.