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目的 总结 19例严重急性呼吸综合征 (SARS)死亡病例的免疫学特点。方法 分析SARS死亡病例的一般临床特征 ,并用流式细胞仪检测T淋巴细胞及其亚群、NK和B细胞绝对计数 ,并与艾滋病 (AIDS)患者及正常对照组比较。结果 SARS死亡病例的淋巴细胞总数、T、T4和T8淋巴细胞绝对数均显著低于AIDS组及正常对照组(P <0 0 0 1) ,4项指标最低值分别为 85个 /mm3 、3 8个 /mm3 、2 6个 /mm3 和 14个 /mm3 ;SARS组的T4/T8淋巴细胞比值高于AIDS组 (P <0 0 0 1) ,与正常对照组无显著性差异 (P =0 8663 ) ;NK和B淋巴细胞低于正常组 (P <0 0 0 1) ,最低值分别为 2个 /mm3 和 17个 /mm3 。结论 SARS患者的细胞和体液免疫功能明显低下。检测T淋巴细胞及其亚群、NK和B细胞绝对数有助于判断SARS患者的病情和预后 ,并对发病早期的辅助诊断有一定意义
Objective To summarize the immunological characteristics of 19 deaths from severe acute respiratory syndrome (SARS). Methods The general clinical features of SARS death cases were analyzed. The absolute count of T lymphocytes and its subsets, NK and B cells were detected by flow cytometry and compared with AIDS patients and normal controls. Results The total number of lymphocytes, the absolute numbers of T, T4 and T8 lymphocytes in SARS patients were significantly lower than those in AIDS and normal controls (P <0.01), and the lowest values of the four indicators were 85 / mm3 and 3 8 / mm3, 26 / mm3 and 14 / mm3. The ratio of T4 / T8 lymphocytes in SARS group was higher than that in AIDS group (P <0.01), which was not significantly different from that in normal control group 8663). The NK and B lymphocytes were lower than the normal group (P <0.01) with the lowest values of 2 / mm3 and 17 / mm3, respectively. Conclusion The cellular and humoral immune function of SARS patients is obviously low. Detection of T lymphocytes and its subsets, the absolute number of NK and B cells can help determine the condition and prognosis of patients with SARS and have some significance for the early diagnosis of the disease