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目的比较大剂量和小剂量胰岛素在治疗糖尿病酮症酸中毒(DKA)患儿中的临床疗效。方法 50例DKA患儿,根据不同治疗方式分为试验组与对照组,各25例。试验组予以小剂量胰岛素,对照组给予大剂量胰岛素。观察并比较两组患儿治疗后一般情况。结果经治疗后,两组在空腹血糖、餐后2 h血糖、尿酮转阴和DKA纠正的时间比较,差异无统计学意义(P>0.05);在血糖降低速度与胰岛素平均剂量比较,差异具有统计学意义(P<0.05)。结论大剂量和小剂量胰岛素在治疗DKA患儿中的疗效相当,但小剂量胰岛素的平均使用量更低,患儿血糖稳定降低。
Objective To compare the clinical efficacy of high-dose and low-dose insulin in the treatment of diabetic ketoacidosis (DKA). Methods 50 cases of DKA children, divided into experimental group and control group according to different treatment methods, each 25 cases. The test group was given a small dose of insulin, the control group given high-dose insulin. Observation and comparison of two groups of children after treatment in general. Results After treatment, there was no significant difference in fasting blood glucose, 2 h postprandial blood glucose, urinary ketone to negative conversion and DKA corrected time (P> 0.05). Compared with the average blood glucose lowering rate, the differences were statistically significant Statistical significance (P <0.05). Conclusion High dose and low dose of insulin in the treatment of DKA in children with similar efficacy, but the average dose of lower doses of insulin lower children with stable blood glucose decreased.