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目的:探讨冠状动脉介入诊疗术前基础血清胱抑素C水平与对比剂肾病(CIN)的关系,并评价其预测CIN的价值。方法:收集2012年1月至2014年1月在本院行冠状动脉介入诊疗术的1 152例患者(CIN组73例,非CIN组1079例)的临床资料,分析术前基础胱抑素C水平与CIN的关系,描绘受试者工作特征(ROC)曲线并计算曲线下面积。结果:本研究人群CIN发生率为6.3%(73/1152)。CIN组术前基础胱抑素C水平高于非CIN组(t=4.033,P<0.001),Logistic回归分析校正年龄、性别、肌酐等因素后,术前基础胱抑素C与CIN独立相关(OR=2.243,95%CI:1.180~4.264,P=0.014)。术前基础胱抑素C的ROC曲线下面积为0.746(95%CI:0.690~0.801)。结论:术前基础胱抑素C水平与CIN密切相关,在预测CIN中有一定的价值。
Objective: To investigate the relationship between preoperative serum cystatin C level and contrast-induced nephropathy (CIN) before PCI and to evaluate the value of predicting CIN. Methods: The clinical data of 1152 patients (73 in CIN group and 1079 in non-CIN group) undergoing coronary artery interventional therapy at our hospital from January 2012 to January 2014 were analyzed retrospectively. Preoperative baseline cystatin C The relationship between levels and CIN, depicting the receiver operating characteristic (ROC) curve and calculating the area under the curve. Results: The incidence of CIN in this study population was 6.3% (73/1152). The preoperative baseline cystatin C level in CIN group was significantly higher than that in non-CIN group (t = 4.033, P <0.001). Logistic regression analysis showed that preoperative baseline cystatin C was independently associated with CIN OR = 2.243, 95% CI: 1.180-4.264, P = 0.014). The area under the ROC curve for preoperative baseline cystatin C was 0.746 (95% CI: 0.690-0.801). Conclusions: The preoperative baseline level of cystatin C is closely related to CIN, and may be of value in predicting CIN.