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抗癌药物的靶向安全输送及远程无损控制释放是提高肿瘤治疗效率并降低毒副作用的前提,但挑战巨大.本文通过原子转移自由基聚合技术在单颗粒Cu_7S_4光热纳米粒子表面嫁接一层温敏高分子,从而设计了一种近红外光热控制智能纳米药物胶囊.该载药纳米胶囊具有较高的抗癌药物(阿霉素)负载能力(19.4%)和良好的光热转换效率(25.4%),并具有合适的药物释放温度(~38°C).在正常生理条件下(37°C,pH 7.4),10 h后仅有10.8%的阿霉素释放,但在808-nm近红外光的照射下,Cu_7S_4将光能转换成热,诱导温敏高分子快速收缩,从而导致所负载的阿霉素被挤出而释放,达到远程光控药物释放的目的.与此同时,Cu_7S_4的光热效应还可用于肿瘤的热疗,该复合纳米胶囊对癌症的化疗与热疗协同疗法将显著提高癌症治疗效果.
Targeted safe delivery and long-distance non-destructive controlled release of anticancer drugs are the preconditions to improve the tumor treatment efficiency and reduce the toxic side effects, but the challenge is huge.In this paper, atom transfer radical polymerization was used to graft a single layer of Cu_7S_4 photothermal nanoparticles Sensitive polymer to design a near-infrared photothermal-controlled intelligent nanocapsules with high loading capacity (19.4%) of anticancer drug (doxorubicin) and good photothermal conversion efficiency ( 25.4%) and had a suitable drug release temperature of ~ 38 ° C. Only 10.8% of doxorubicin was released after 10 h under normal physiological conditions (37 ° C, pH 7.4) but at 808-nm Under the irradiation of near-infrared light, Cu_7S_4 converts light energy into heat, induces rapid contraction of temperature-sensitive polymers, resulting in the release of doxorubicin loaded to achieve the purpose of remote photocontrol drug release.At the same time, The photothermal effect of Cu_7S_4 can also be used for tumor hyperthermia. The combination of chemotherapy and hyperthermia with the composite nanocapsules will significantly improve the effect of cancer treatment.