本文作者在国内外首次报告缺铁诱发的大鼠耳蜗病理模型。听觉电生理、组织病理、酶组织化学与生物化学以及扫描电镜研究结果表明,铁缺乏可直接影响耳蜗含铁酶活性,导致血管纹萎缩,螺旋神经节细胞密度减少和听毛细胞静纤毛损伤,引起感觉神经性聋或造成其发生的病理基础。这一发现为听力学与耳聋防治学提供了新的重要理论和实验依据。 The authors report for the first time in the world of iron deficiency-induced rat cochlear pathology model. Auditory electrophysiology, histopathology, enzyme histochemistry and biochemistry and scanning electron microscopy showed that iron deficiency could directly affect iron-containing enzyme activity in the cochlea, leading to atrophy of the stria vascularis, reduction of the density of spiral ganglion cells, and ciliary cilia damage in the hair cells, Causes sensory nerve deafness or causes its pathological basis. This finding provides new important theoretical and experimental evidences for the prevention and treatment of audiology and deafness.