骨桥蛋白是细胞外基质的重要成分它含有RGD序列,其主要受体为整合素αVβ3,二者相互作用共同参与一系列重要的生理、病理过程。研究发现子宫内膜、滋养细胞均表达骨桥蛋白,且其在内膜中的表达随月经周期而变化,高表达于内膜的种植窗,推测与内膜容受性的建立及受精卵的种植有关。 Osteopontin is an important component of extracellular matrix which contains RGD sequence. Its main receptor is integrin αVβ3, which interacts with a series of important physiological and pathological processes. The study found that endometrial and trophoblast cells express osteopontin, and its expression in the intima changes with the menstrual cycle, high expression in the endometrial implantation window, presumably with the establishment of endometrial receptivity and fertilized eggs Planting related.