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目的了解不同孕期妇女血清β-hCG水平的变化与甲状腺激素水平变化之间的关系。方法随机抽取孕早期、孕中期和孕晚期妇女各50例。按不同孕期分为3组，用化学发光法分别检测其血清β-hCG水平及总T3、总T4、FT3、FT4和TSH水平，比较各组间β-hCG水平及甲状腺激素水平的变化特点。结果(1)孕早期的FT3、FT4和TSH水平与孕中期相近。(2)孕早、中期的FT3、FT4高于孕晚期，而TSH低于孕晚期。结论妊娠期母体免疫状态的改变可能才是主要因素，孕妇甲状腺功能紊乱主要由自身免疫性因素所致。“,” Objective Understanding pregnant women,s serum β-HCG levels in between changes in thyroid hormone levels.Methods Random pregnant early, pregnant middle and late pregnancy women in 50 cases. Different pregnancy is divided into 3 groups, respectively by using chemiluminescence detection of its serum β-HCG level and total T3and total T4, andFT3, andFT4 , TSH levels, comparisons between the groups β-HCG levels and thyroid hormone level changes. Results (1) first trimester of FT3and theFT4 , TSH levels close to the second trimester. (2) early and mid gestation FT3and theFT4 is higher than in late pregnancy, and TSH is lower than in late pregnancy . Conclusion Change of maternal immunity during pregnancy may be the main factor, women mainly caused by autoimmune factors of thyroid dysfunction.