肝小静脉闭塞病(VOD)是指以肝小叶中央静脉和小叶下静脉等小静脉分支内非血栓性阻塞所引起的疾病,临床表现为肝肿大、右上腹疼痛,黄疸和腹水。1953年由Hill等首次报道,当时称之为“浆液性肝病”。目前本病的发病机制尚不十分清楚,可能和凝血系统激活、炎性因子、肝脏解毒作用等多因素有关。 Hepatic veno-occlusive disease (VOD) is a disease caused by non-thrombus occlusion within the small vein branches such as the hepatic lobule central vein and the hypoglossal vein. Clinical manifestations include hepatomegaly, right upper quadrant pain, jaundice, and ascites. First reported by Hill et al in 1953, was called “serous liver disease.” The pathogenesis of this disease is not yet very clear, and may be activated coagulation system, inflammatory factors, liver detoxification and other factors.