多药耐药是临床肿瘤化疗失败的主要原因,为此必须寻找有效的耐药逆转剂。近年来发现米非司酮能通过以下途径逆转耐药:降低P-糖蛋白和多药耐药相关蛋白对药物的外排作用,增加细胞内药物浓度;阻断神经酰胺向葡萄糖基化神经酰胺的转化,促进细胞凋亡。而且与其他逆转剂相比,米非司酮所需浓度低,对人体无明显副作用,因此有较广阔的临床应用前景。 Multidrug resistance is the main reason for the failure of clinical tumor chemotherapy, therefore, we must find an effective drug resistance reversal agent. In recent years, mifepristone has been found to be able to reverse drug resistance by decreasing the efflux of drugs such as P-glycoprotein and multidrug resistance-related proteins and increasing intracellular drug concentrations; blocking ceramide delivery to glucosylated ceramide The transformation, promote apoptosis. And compared with other adverse agents, low concentrations of mifepristone, no significant side effects on the human body, so there is a broader clinical application prospects.