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作者对84例肾病综合征进行了部分免疫学检查,包括免疫球蛋白、补体C3和淋巴母细胞转化试验。根据临床表现及化验检查将全部病例分为单纯型及肾炎型。按治疗前后为序分为3期:Ⅰ型为未治或初治期,Ⅱ期为用药期,Ⅲ期为缓解期。观察结果如下: 一、血清免疫球蛋白:单纯型Ⅰ期IgG、IgA各测定67例,IgM测定66例,与国内同年龄组健康儿童相比均有部分病例减低。IgG减低最明显,57例(85％)低于正常低值。IgA有4例高于正常范围,14例(20.9％)低于正常范围。IgM有6例高于正常范围,17例(25.75％)低于正常范围。Ⅱ期各测定14例,Ⅲ期各测定27例,IgG随治疗过程逐渐恢复,IgA未见太大变化,IgM在Ⅲ期低于正常者增加至40.74％。 17例肾炎型Ⅰ期,IgG13例(75.5％)低于正常,IgA3例(17.64％)低于正常,1例高于正常,IgM低于或高于正常各1例。二、补体C3约1/3病例高于正常范围,1/4病例低于正常范围。三、淋巴母细胞转化试验多数正常,单纯型Ⅰ期约2/5转化率稍低于正常。
The authors conducted a partial immunological examination of 84 patients with nephrotic syndrome, including immunoglobulin, complement C3, and lymphoblastoid transformation assays. All cases were divided into simple type and nephritis according to clinical manifestations and laboratory tests. According to the order of treatment before and after divided into 3: Ⅰ type of untreated or naive, Ⅱ period for the medication period, Ⅲ for the remission. The results are as follows: First, the serum immunoglobulin: simple type Ⅰ IgG, IgA determination of 67 cases, IgM determination of 66 cases, compared with the same age group of healthy children in some cases were reduced. The most significant decrease was in IgG, 57 (85%) below normal. 4 cases of IgA were higher than the normal range and 14 cases (20.9%) were lower than the normal range. Six cases of IgM were higher than the normal range and 17 cases (25.75%) were below the normal range. There were 14 cases in stage Ⅱ, 27 cases in stage Ⅲ, and IgG recovered gradually with the course of treatment. There was not much change in IgA, and the level of IgM in stage Ⅲ was 40.74% lower than normal. In the 17 cases of nephritis type I, 13 cases of IgG (75.5%) were lower than normal, 3 cases (17.64%) of IgA were lower than normal, 1 case was higher than normal and IgM was lower or higher than normal in 1 case. Second, complement C3 about 1/3 cases higher than the normal range, 1/4 cases lower than the normal range. Third, most of the normal lymphoblast transformation test, simple type Ⅰ about 2/5 conversion rate slightly lower than normal.