,Restrictive versus liberal fluid therapy for major abdominal surgery: is the evidence strong?

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We have read with great interest the original study by Myles et al. (1), in which the authors claimed a restrictive fluid regimen during and up to 24 hours after major abdominal surgery was associated with higher rate of acute kidney injury. This inteational, randomized, assessor-blinded trail compared the following outcomes between restrictive and liberal intravenous-fluid regimen: disability-free survival at 1 year, acute kidney injury at 30 days, renal-replacement therapy at 90 days, septic complications, surgical-site infection, and death. The perioperative fluid management is of great clinical significance, the results demonstrated by Myles et al. provide high-level evidence with dedicate design and adequate case volume, serving as potential reference to guidelines of surgical patient care. Shortly after its online publication, the article has drawn tremendous attention and caused extensive discussion among surgeons world-wide.
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