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目的探讨胰岛样生长因子 1(IGF- 1)与 2型糖尿病 (DM)合并糖尿病肾病 (DN)肾功能损害程度的相关关系。方法采用免放法检测血清 IGF- 1水平 ;采用放免法检测尿白蛋白。结果 1方差分析显示各组间血清 IGF- 1水平有显著性差异 (F值 2 4.5 4,P值 0 .0 0 0 1) ,其中临床期 DN组 (33例 )明显高于隐匿期 DN组 (46例 )和非 DN组 (79例 )以及健康对照组 (5 0例 ) ,后 3组间相互比较无显著性差异 ;2逐步回归分析显示 IGF- 1和空腹胰岛素(FI)与尿白蛋白排泄率 (UAE)正相关 ,FBG、PBG、Hb A1 C、TC、TG、HDL - C和 L DL - C等 7个因素与 UAE无显著性关系。结论 IGF- 1可作为反映 2型 DM肾病病情严重程度的指标 ,同时也可能是 2型 DM肾病的发病因素之一。
Objective To investigate the relationship between islet-like growth factor-1 (IGF-1) and the degree of renal dysfunction in type 2 diabetes mellitus (DM) with diabetic nephropathy (DN). Methods The level of serum IGF-1 was measured by immunoassay. Urinary albumin was detected by radioimmunoassay. Results 1 ANOVA showed that there was a significant difference in serum IGF-1 levels between groups (F = 4.554, P = 0.0001), of which the clinical stage DN group (33 cases) was significantly higher than that of the DN stage (46 cases) and non-DN group (79 cases), and healthy control group (50 cases). There was no significant difference between the three groups afterwards. (2) Stepwise regression analysis showed that IGF-1 and fasting insulin (FI) There was a positive correlation between UAE and UAE. There were no significant relationships between UAE and FBG, PBG, Hb A1 C, TC, TG, HDL - C and L DL - C. Conclusion IGF-1 may be used as an indicator of the severity of type 2 DM nephropathy and may be one of the pathogenesis of type 2 DM nephropathy.