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目的探讨小儿肺炎支原体(MP)感染与支气管哮喘(BA)的相关性。方法选取2012年5月-2014年5月84例BA患儿和84例小儿呼吸道感染患儿,分别作为BA组和呼吸道感染组。检测血清MP-免疫球蛋白M(Ig M),同时检测BA组MP-Ig M阳性、阴性患儿嗜酸性粒细胞计数(EOS)、白细胞(WBC)、降钙素原(PCT)和超敏C反应蛋白(hs-CRP)水平。结果 BA组血清MP-Ig M阳性率明显高于呼吸道感染组(40.48%vs 14.29%),差异有统计学意义(P<0.01);BA组MPIg M阳性患儿EOS、hs-CRP水平均明显高于MP-Ig M阴性患儿(516.7±49.6 vs 434.4±33.7;10.9±2.7 vs 5.5±1.3),差异有统计学意义(P<0.05或P<0.01),MP-Ig M阳性患儿WBC、PCT水平与MP-Ig M阴性患儿比较,差异无统计学意义(P>0.05)。结论小儿BA与MP感染密切相关,加强对BA患儿支原体检查,对于BA患儿诊断与预后具有积极的临床价值。
Objective To investigate the relationship between Mycoplasma pneumoniae (MP) infection and bronchial asthma (BA) in children. Methods From May 2012 to May 2014, 84 infants with BA and 84 children with respiratory tract infection were selected as BA and respiratory tract infection group respectively. Serum MP-immunoglobulin M (Ig M) was detected and the MP-Ig M positive and negative eosinophil count (EOS), white blood cell (WBC), procalcitonin (PCT) C-reactive protein (hs-CRP) levels. Results The positive rate of MP-Ig M in BA group was significantly higher than that in respiratory tract infection group (40.48% vs 14.29%, P <0.01). The levels of EOS and hs-CRP in BA group were significantly higher than those in MPIg M group (516.7 ± 49.6 vs 434.4 ± 33.7; 10.9 ± 2.7 vs 5.5 ± 1.3, P <0.05 or P <0.01). The WBC of MP-Ig M positive children There was no significant difference in PCT level between the two groups (P> 0.05). Conclusion There is a close relationship between BA and MP infection in children. Strengthening mycoplasma examination in children with BA has positive clinical value for the diagnosis and prognosis of children with BA.