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目的探讨两种不同的黄体支持方案在体外受精-胚胎移植(IVF-ET)治疗周期中的应用及对妊娠结局的影响。方法对2015年3月1日至8月31日于生殖中心取卵并于新鲜周期移植的患者603例随机分为A组305例、B组298例。黄体支持方案A组为地屈孕酮(口服)联合雪诺同(阴道给药),B组为黄体酮(肌肉注射)联合雪诺同(阴道给药)。结果两组患者年龄、不孕年限、BMI、基础内分泌、HCG日激素、内膜厚度、移植胚胎数、临床妊娠率和种植率差异均无统计学意义。A组无明显不良反应;B组有28例出现臀部硬结,经局部热敷后均不同程度好转。结论两种黄体支持方案对IVF-ET治疗周期均有效。地屈孕酮联合雪诺同使用简便,患者满意度高、依从性好,可避免肌肉注射产生的痛苦及不良反应,节省费用,减少工作量,值得临床推广应用。
Objective To investigate the application of two different luteal support protocols in IVF-ET cycles and their effects on pregnancy outcomes. Methods A total of 603 patients with ovulation in the reproductive center from March 1 to August 31, 2015 in the fresh cycle were randomly divided into A group (305 cases) and B group (298 cases). Luteal support group A was droperidone (oral) combined with Snow promise (vaginal), and group B was progesterone (intramuscular injection) combined with Snow promise (vaginal). Results There were no significant differences in age, duration of infertility, BMI, basal endocrine, HCG, endometrial thickness, number of embryos transferred, clinical pregnancy rate and implantation rate. There was no obvious adverse reaction in group A, while in group B, 28 cases showed hip induration, which were all improved to different degrees after local heat application. Conclusions Both luteal support protocols are effective for IVF-ET treatment cycles. Dydrogesterone combined with Snow Connaught easy to use, patients with high satisfaction, good compliance, can avoid the pain and adverse reactions caused by intramuscular injection, save costs and reduce workload, it is worth promoting the clinical application.