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溶液的PH值与温度是影响药物水解的主要因素。调整PH值于稳定区域是防止或延缓水解的重要措施。加HCl调整PH值通常采用稀释定律:〔H+〕1·V1=〔H+〕2·V2(1)求取酸用量,式(1)计算适用于葡萄糖、低分子右旋糖酐等注射液的PH值调整,但不适用于弱
Solution pH and temperature are the main factors that affect drug hydrolysis. Adjusting the pH in the stable zone is an important measure to prevent or retard hydrolysis. The adjustment of PH value with HCl usually adopts the dilution law: [H +] 1 · V1 = [H +] 2 · V2 (1) Calculate the amount of acid used to calculate the pH value of the injection solution of glucose, low molecular weight dextran and the like , But not for weakness