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目的观察择期剖宫产围手术期抗生素不同预防应用方法的效果,探讨合理的应用方式。方法随机选择2009年1月～2010年1月期间择期剖宫产产妇280例,随机分为观察组及对照组各140例。观察组断脐之后将头胞噻肟钠2.0g药液溶于50～100mL输液中于20～30min内静脉滴入,术后持续用药时间不超过24h,如有营养不良、糖尿病、免疫功能低下、严重系统疾病考虑适当延长,不应超过3d;对照组术前、术中未用药,术后回病房应用头胞噻肟钠2.0g药液溶于50～100mL输液中于20～30min滴注,2次/d,连续3～5d。结果两组产妇术后病率及发热、产褥期相关感染无显著性差异(P>0.05);与对照组比较,观察组抗生素应用时间及术后住院时间较短(P<0.05)。结论择期剖宫产术前应用单剂、术后短时间应用抗生素是一种合理有效的给药方式,值得临床推广。
Objective To observe the effect of different prophylactic and prophylactic methods of perioperative antibiotics in cesarean section during elective cesarean section and to explore the reasonable application methods. Methods 280 cases of elective cesarean section were randomly selected from January 2009 to January 2010, and randomly divided into observation group and control group with 140 cases each. The observation group after the umbilical cephalosporin sodium 2.0g solution dissolved in 50 ~ 100mL infusion in 20 ~ 30min intravenous infusion, continued treatment for no more than 24h, if malnutrition, diabetes, immune dysfunction , Severe systemic diseases considered appropriate to extend, should not exceed 3d; control group before surgery, intraoperative no medication, postoperative ward application of cefotaxime sodium 2.0g solution dissolved in 50 ~ 100mL infusion at 20 ~ 30min instillation , 2 times / d, continuous 3 ~ 5d. Results There was no significant difference in postoperative morbidity, fever and puerperium-related infection between the two groups (P> 0.05). Compared with the control group, antibiotic application time and postoperative hospital stay in the observation group were shorter (P <0.05). Conclusion Elective cesarean section preoperative elective, short-term application of antibiotics is a reasonable and effective mode of administration, worthy of clinical promotion.