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目的探讨血清补体C3a的检测对胃癌诊治的临床价值。方法用酶联免疫吸附法检测胃癌、大肠癌、食管癌以及胃良性疾病患者和健康人的血清补体C3a水平。结果胃癌患者血清补体C3a水平明显高于其他各组(P<0.01)。胃良性疾病患者、大肠癌、食管癌组血清补体C3a水平与健康人比较差异无显著性(P>0.05)。胃癌患者手术后血清补体C3a水平明显下降。结论血清补体C3a检测对胃癌的辅助诊断、监测疗效、判断预后具有一定的临床应用价值,可能成为一种新的胃癌肿瘤标志物。
Objective To investigate the clinical value of serum complement C3a in the diagnosis and treatment of gastric cancer. Methods The levels of serum complement C3a in gastric cancer, colorectal cancer, esophageal cancer, gastric benign disease and healthy people were detected by enzyme-linked immunosorbent assay. Results Serum complement C3a levels in patients with gastric cancer were significantly higher than those in other groups (P <0.01). Gastric benign disease patients, colorectal cancer, esophageal cancer serum complement C3a levels compared with healthy people no significant difference (P> 0.05). Gastric cancer patients after surgery serum complement C3a levels decreased significantly. Conclusion Serum complement C3a test may be of clinical value in the diagnosis, monitoring and prognosis of gastric cancer, and may be a new tumor marker of gastric cancer.