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Total synthesis of N-methylsansalvamide A was accomplished in solution phase by a convergent approach. An N-Boc-tri-depsipepide 6 and a dipeptide ester 10 were prepared in the yield of 89% and 91%, respectively. Cyclization of the linear penta-depsipetide was achieved with PyBOP and DIPEA in DMF-CH2Cl2.