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目的分析Ｘ线立体定向放射治疗（ＳｔｅｒｅｏｔａｃｔｉｃＲａｄｉｏｔｈｅｒａｐｙ，ＳＲＴ）加全脑放疗降低脑转移瘤局部复发的意义。材料与方法１９９６年５月至１９９７年１０月间对６５例脑转移瘤患者行ＳＲＴ加全脑放疗３０例，单纯ＳＲＴ治疗３５例。全脑放疗３８～４０Ｇｙ／４～４．５周。ＳＲＴ周边剂量１５～３２Ｇｙ。结果ＳＲＴ加全脑放疗组中位复发时间９．５个月，局部复发率３．３％，显著优于单纯ＳＲＴ治疗组的３个月和２８．６％（Ｐ＜０．０５）；ＳＲＴ加全脑放疗组局部控制率９３．６％，中位生存时间１０个月，１年生存率８３．３％和死亡率１６．７％与对照组９２．９％，７个月，７１．４％和２８．６％比较差异无显著意义（Ｐ＞０．０５）。结论ＳＲＴ加全脑放疗治疗脑转移瘤在控制局部复发，延长复发时间方面优于单纯ＳＲＴ治疗
Objective To analyze the significance of SRT and whole brain radiotherapy in reducing local recurrence of brain metastases. Materials and Methods From May 1996 to October 1997, 65 patients with brain metastases underwent SRT plus whole-brain radiotherapy in 30 cases and SRT alone in 35 cases. Whole-brain radiotherapy 38 ~ 40Gy / 4 ~ 4.5 weeks. SRT peripheral dose 15 ~ 32Gy. Results The median time to recurrence was 9.5 months in SRT plus whole brain radiotherapy and 3.3% in local recurrence, which was significantly better than that in SRT alone group (28.6%, P <0.05). SRT Plus global brain radiotherapy group local control rate of 93.6%, median survival time of 10 months, 1-year survival rate of 83.3% and mortality rate of 16.7% compared with the control group 92.9%, 7 months, 71. There was no significant difference between 4% and 28.6% (P> 0.05). Conclusion SRT plus whole brain radiotherapy in the treatment of brain metastases is superior to SRT alone in controlling local recurrence and prolonging the recurrence time