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患者男,22岁,75年9月4日诊断为再障,半年前曾服用氯霉素,服用克林特霉素近1年。体检:苍白外貌,四肢散在瘀点和广泛视网膜出血。红细胞比积14％,白细胞1,700,中性占8％,血小板7,000,网织红细胞0.3％,骨髓检查增生明显低下,以淋巴细胞和浆细胞为主。糖水试验和酸化血清试验阴性,其他化验均正常。因找不到HLA相容的供骨髓者,不能作骨髓移殖,先后服用大力补,强的松,输注血小板和红细胞等均无效。以后病情恶化,出血感染等相继发生。输血小板因发生了同种过敏反应而无效。于11月16日接受环磷酰胺30毫克/公斤/天共4天,治疗后
Male patient, 22 years old, diagnosed as aplastic anemia on September 4, 75, took chloramphenicol six months ago and took clindamycin nearly one year. Physical examination: pale appearance, scattered limbs and extensive retinal bleeding. Hematocrit 14%, leucocyte 1,700, neutral 8%, platelet 7,000, reticulocyte 0.3%, significantly lower bone marrow hyperplasia, mainly lymphocytes and plasma cells. Sugar test and acidified serum test negative, other tests were normal. Can not be HLA compatible for bone marrow, can not be used for bone marrow transplantation, has taken vigorous Buxus, prednisone, transfusion platelets and red blood cells were invalid. After the condition deteriorated, bleeding infections have occurred. Platelet transfusion due to the same kind of allergic reaction and invalid. Cyclophosphamide 30 mg / kg / day for a total of 4 days on Nov. 16 after treatment