论文部分内容阅读
目的：探讨地塞米松治疗妊娠肝内胆汁瘀积症（ＩＣＰ）的临床效果。方法：将１９９７１９９８ 年度在我院住院的１２８ 例ＩＣＰ患者随机分成两组：ＩＣＰ甲组，口服地塞米松１２ｇ／ 天，连服四天，以后逐渐减量，７ 天为１ 疗程；ＩＣＰ乙组，静脉推注地塞米松１０ｇ／天，２ 天为１ 疗程。结果：两组的瘙痒发生率均显著下降（Ｐ＜ ０－０５） ；甘胆酸、血总胆汁酸、总胆红素、直接胆红素、血雌三醇，ＩＣＰ甲组明显低于治疗前，有显著差异（Ｐ＜ ０－０５） ，ＩＣＰ乙组于治疗前后无显著差异（Ｐ＞ ０－０５） ；ＩＣＰ甲组黄疸４ 例有３例好转，ＩＣＰ乙组５ 例效果都不明显；胎儿窘迫率、新生儿窒息率、剖宫产率，ＩＣＰ甲组明显低于乙组（Ｐ＜ ０－０５） ；谷丙转氨酶、谷草转氨酶，二组治疗前后无明显差异。结论：口服地塞米松一周疗法明显好于静脉推注二天疗法，因此，口服地塞米松１ 周疗法可作为治疗ＩＣＰ的较佳方案；而且地塞米松可以作为治疗ＩＣＰ的首选药。
Objective: To investigate the clinical effect of dexamethasone on intrahepatic cholestasis of pregnancy (ICP). Methods: A total of 128 ICP patients hospitalized in our hospital from 1997 to 1998 were randomly divided into two groups: ICP group A, oral dexamethasone 12g / day, and even for four days, then gradually reduced, 7 days for a course of treatment; ICP Group B, intravenous dexamethasone 10g / day, 2 days for a course of treatment. Results: The incidence of pruritus decreased significantly in both groups (P <0-05). The levels of glycocholate, total bile acid, total bilirubin, direct bilirubin, blood estriol and ICP group were significantly lower than those of the treatment group (P <0-05), there was no significant difference in ICP B group before and after treatment (P> 0-05); in 4 cases of ICP group jaundice, 3 cases improved, while 5 cases in ICP B group were not obvious Fetal distress rate, neonatal asphyxia rate and cesarean section rate were significantly lower in ICP group than in group B (P <0-05). There was no significant difference between the two groups before and after treatment with alanine aminotransferase and aspartate aminotransferase. Conclusion: One-week oral dexamethasone treatment is significantly better than intravenous injection of two days therapy, therefore, oral dexamethasone week therapy can be used as a better program for the treatment of ICP; and dexamethasone can be used as the preferred drug for the treatment of ICP.