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目的探讨肝硬化患者医源性感染的相关因素,为预防医源性感染提供依据。方法对217例肝硬化患者临床资料进行回顾性分析,研究医源性感染发生率和感染部位;观察与医源性感染有关的因素,如年龄,性别、肝功能、白细胞、凝血酶原时间、实施侵袭性操作、腹水情况、Child-Pugh分级、预防性使用抗菌素等。结果医源性感染率为19.3%;与医源性感染相关因素是预防性使用抗菌素﹑实施侵袭性操作﹑白蛋白水平和Child-Pugh分级(P<0.05),具有统计学意义。结论肝硬化患者医源性感染危险因素较多,要注意纠正低蛋白血症,积极改善肝功能,及减少不必要的侵袭性操作。
Objective To investigate the related factors of iatrogenic infection in cirrhotic patients and provide basis for prevention of iatrogenic infection. Methods The clinical data of 217 patients with cirrhosis were analyzed retrospectively to study the incidence and location of iatrogenic infection. The factors related to iatrogenic infection were observed, such as age, sex, liver function, leukocyte count, prothrombin time, Perform invasive procedures, ascites, Child-Pugh grading, prophylactic use of antibiotics and more. Results The rate of iatrogenic infection was 19.3%. The factors related to iatrogenic infection were prophylactic use of antibiotics, aggressive operation, albumin level and Child-Pugh classification (P <0.05), which were statistically significant. Conclusion There are many risk factors for iatrogenic infection in patients with cirrhosis. Attention should be paid to correct hypoproteinemia, improve liver function actively, and reduce unnecessary invasive operation.