论文部分内容阅读
目的 探讨肾小球疾病患者血浆纤维蛋白原 (FIB)浓度及其临床意义。方法 经肾活检证实的肾小球疾病患者 333例 ,其中非肾病范围蛋白尿 177例 (A组 ) ;肾病范围蛋白尿 15 6例 (B组 ) ,比较两组FIB与白蛋白 (ALB)、尿蛋白排泄量 (U pro)、总胆固醇 (TC)及甘油三酯 (TG)浓度间的相关性。 结果 A组FIB与上述指标无明显相关 (P >0 .0 5 ) ;B组FIB与ALB负相关 (r =- 0 .5 7,P <0 .0 1) ,与U pro、TC及TG正相关 (r分别为 0 .376 ,0 .4 95和 0 .19,P <0 .0 1,<0 .0 1和 =0 .0 17)。FIB >8.0 g/L者易发生血栓、栓塞。结论 尿蛋白排泄量越大、白蛋白浓度越低则FIB和血脂浓度越高 ,FIB >8.0 g/L者有诱因 (如脱水 )存在时易形成血栓
Objective To investigate the plasma fibrinogen (FIB) concentration in patients with glomerular diseases and its clinical significance. Methods A total of 333 patients with glomerular disease confirmed by renal biopsy were enrolled, including 177 cases of albuminuria (group A), 15 6 cases of nephropathy (group B), FIB and albumin (ALB) Urinary protein excretion (U pro), total cholesterol (TC) and triglyceride (TG) concentrations. Results There was no significant correlation between the FIB and the above indexes in group A (P> 0.05). The FIB in group B was negatively correlated with ALB (r = - 0.57, P <0.01) (R = 0 .376, 0 .495 and 0.19 respectively, P <0. 01, <0. 01 and = 0. 0 17). FIB> 8.0 g / L are prone to thrombosis, embolism. Conclusions The larger the urinary protein excretion, the lower the albumin concentration, the higher the FIB and serum lipids, and the higher the FIB> 8.0 g / L, the predisposition (such as dehydration) may form thrombus