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目的 探讨鼻腔嗅神经母细胞瘤综合治疗价值 方法 １９８０ ～１９９８ 年６ 月我科共收治６ 例鼻腔嗅神经母细胞瘤，均经病理学证实，男４ 例，女２ 例。年龄２１ ～６５ 岁，平均４９ 岁。所有病人首发症状均表现为持续性鼻塞或鼻衄，病程在２～１４ 个月。５ 例初诊时被误诊为鼻息肉等。根据Ｋａｄｉｓｈ 分期：Ａ期１ 例，Ｂ期４例，Ｃ期１ 例。５ 例行手术加放疗综合治疗方式，１ 例术后７ 个月复发，再次手术后加放疗。结果 本组３ 例治疗后超过５ 年，其中２ 例分别无瘤生存５ 年和７ 年，１ 例生存６ 年后失访。另３ 例治疗后时间较短，２ 例分别无瘤生存５ 个月和１８ 个月，１ 例手术切除不干净，放疗后生存１ 年死于局部复发。所有病人治疗后未发现颈部淋巴结及其它部位转移。结论 作者认为手术加放疗是治疗鼻腔嗅神经母细胞瘤的有效治疗手段。
Objective To investigate the value of comprehensive therapy for nasal olfactory neuroblastoma. Methods From June 1980 to June 1998, 6 cases of nasal olfactory neuroblastoma were treated in our department. All of them were confirmed by pathology. There were 4 males and 2 females. Ages 21 to 65 years, average 49 years old. The first symptom in all patients was persistent nasal congestion or epistaxis, and the duration ranged from 2 to 14 months. Five cases were misdiagnosed as nasal polyps when they were first diagnosed. According to Kadish’s staging: 1 case in A stage, 4 cases in B stage, and 1 case in C stage. 5 Routine surgery and radiotherapy combined therapy, 1 case of recurrence 7 months after surgery, plus radiotherapy after surgery. Results The 3 patients in this group had been treated for more than 5 years, 2 of them had tumor-free survival for 5 years and 7 years respectively, and 1 patient lost their follow-up after 6 years of survival. The other 3 patients had a short time after treatment. 2 patients survived for 5 months and 18 months without tumor, respectively. One patient had unclean surgical resection and died of local recurrence after 1 year of radiation therapy. No lymph node metastasis and other metastases were found in all patients after treatment. Conclusion The authors believe that surgery plus radiotherapy is an effective treatment for nasal olfactory neuroblastoma.