论文部分内容阅读
目的:观察天花粉蛋白注射液联合甲氨蝶呤治疗胎盘植入的临床效果。方法:将胎盘植入保守治疗患者80例,随机分为2组各40例。对照组采用甲氨蝶呤进行治疗,观察组在对照组的基础上联合天花粉蛋白注射液治疗,观察比较2组患者临床疗效,同时观测血清β-HCG水平、宫腔内病灶面积的变化。结果:治愈率观察组为92.50%,对照组为72.50%,2组比较,差异有统计学意义(P<0.05)。治疗后1、10、20天,2组血清β-HCG水平均较治疗前降低(P<0.05),且治疗组上述各时段β-HCG水平降低较对照组更显著(P<0.05)。治疗后7、14天,2组宫腔内病灶面积均较治疗前缩小(P<0.05),且治疗组上述各时段病灶面积缩小较对照组更显著(P<0.05)。结论:天花粉蛋白注射液联合甲氨蝶呤对胎盘植入保守治疗的临床效果优于单独使用甲氨蝶呤,并能快速降低血清β-HCG水平,缩小宫腔内病灶面积,值得临床合理选用。
Objective: To observe the clinical effect of trichosanthin injection combined with methotrexate in the treatment of placenta accreta. Methods: 80 cases of placenta accretated conservative treatment were randomly divided into two groups of 40 cases. The control group was treated with methotrexate. The observation group was treated with trichosanthin injection on the basis of the control group. The clinical curative effect was observed and compared between the two groups. The level of serum β-HCG and the intrauterine lesion area were also observed. Results: The cure rate was 92.50% in the observation group and 72.50% in the control group. There was significant difference between the two groups (P <0.05). At 1, 10 and 20 days after treatment, the levels of serum β-HCG in both groups were significantly lower than those before treatment (P <0.05), and the levels of β-HCG in the treatment group were significantly lower than those in the control group at the same time point (P <0.05). At 7 and 14 days after treatment, the intrauterine lesion size of the two groups decreased compared with that before treatment (P <0.05), and the lesion size of the treated group was more significant than that of the control group at 7 and 14 days after treatment (P <0.05). Conclusion: Trichosanthin injection combined with methotrexate on the conservative treatment of placenta accreta is superior to methotrexate alone, and can rapidly reduce the level of serum β-HCG and reduce the area of intrauterine lesions, it is clinically rational selection .