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目的探讨结直肠癌肺转移患者的临床特征及预后生存分析。方法选取2008年1月至2014年1月间福建医科大学附属第一医院收治的146例结直肠癌肺转移患者的临床资料及随访资料,分析患者的临床特征及影响结直肠癌肺转移患者预后的相关因素。结果患者中位随访时间为35.1个月,中位生存时间为27.1个月,1年、3年和5年生存率分别为75.3%、30.8%和12.4%。病理组织分级、TNM肿瘤分期、肺转移灶大小、肺转移灶数目、是否合并肝转移和治疗方式不同的结直肠癌肺转移患者,预后生存时间差异均有统计学意义(均P<0.05)。低分化结直肠癌、高TNM分期、合并肝转移及单纯化疗是影响结直肠癌肺转移患者预后生存的独立危险因素,差异有统计学意义(P<0.001)。结论结直肠癌肺转移患者预后较差,低分化、高TNM分期、合并肝转移及单纯化疗是影响患者预后生存的危险因素,积极进行综合治疗可提高预后疗效。
Objective To investigate the clinical characteristics and prognosis of patients with lung metastasis of colorectal cancer. Methods The clinical data and follow-up data of 146 patients with lung metastasis of colorectal cancer who were admitted to the First Affiliated Hospital of Fujian Medical University from January 2008 to January 2014 were analyzed. The clinical characteristics and the prognosis of patients with lung metastasis of colorectal cancer Related factors. Results The median follow-up time was 35.1 months, the median survival time was 27.1 months, and the 1-year, 3-year and 5-year survival rates were 75.3%, 30.8% and 12.4%, respectively. There were significant differences in prognosis of patients with lung metastasis of colorectal cancer with histological grading, TNM staging, lung metastases size, number of lung metastases, and whether they were associated with liver metastases and treatment methods (all P <0.05). Poorly differentiated colorectal cancer, high TNM stage, combined liver metastasis and chemotherapy alone were independent risk factors for prognosis of colorectal cancer patients with lung metastasis, the difference was statistically significant (P <0.001). Conclusions Patients with lung metastasis of colorectal cancer have a poor prognosis. Poorly differentiated, high TNM staging, combined liver metastasis and chemotherapy alone are risk factors for prognosis of patients. Active treatment can improve prognosis.