论文部分内容阅读
组蛋白去乙酰化酶抑制剂(histone deacetylases inhi-bitors,HDACIs)是一类在转录水平调控基因表达的化合物,通过诱导蛋白过乙酰化引起染色体重建、细胞周期停滞、诱导细胞分化和凋亡以及调节转录因子活化和抑制等一系列生物学效应。HDACIs在多种血液系统肿瘤和实体瘤中显示了明确而强大的抗肿瘤活性,目前已进入临床研究阶段。其在炎症免疫疾病动物模型及基础研究中显示出的免疫抑
Histone deacetylases inhi-bitors (HDACIs) are a class of compounds that regulate gene expression at the transcriptional level by inducing chromatin remodeling, cell cycle arrest, cell differentiation and apoptosis induced by proteinaceous peracetylation Regulation of transcription factor activation and inhibition and a series of biological effects. HDACIs have demonstrated clear and potent anti-tumor activity in a variety of hematological and solid tumors and are currently in clinical trials. It shows immunosuppression in animal models of inflammatory disease and basic research