包括鼠疫在内的一系列细菌性感染,在其发病机理中总可在机体的细胞(尤其是吞噬细胞)内观察到病原体的存在(那怕是短时间的存在也罢)。故寻找和合成可渗入细胞的药物,迫在眉睫。众所周知,四环素依靠中性分子或两性分子,可迅速渗入细菌细胞和机体细胞。抗菌素作用于细胞内的细菌取决于多种因素, A series of bacterial infections, including the plague, has always been present in the pathogenesis of pathogens, especially in phagocytes, even for short periods of time. Therefore, looking for and synthesis of cells that can penetrate the drug, imminent. As we all know, tetracycline relies on neutral molecules or amphipathic molecules, can quickly penetrate into bacterial cells and body cells. Antibiotics The action of bacteria in cells depends on many factors,