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曾受b型流感杆菌(Hib)感染的2岁以内儿童,体内可能不产生抗Hib荚膜多糖(PRP)保护性抗体,有再次感染的危险。作者给有Hib感染史的儿童接种b型流感杆菌结合菌苗,以评价该结合菌苗对儿童的免疫原性和安全性。结合菌苗系由b型流感杆菌荚膜多糖与B群脑膜炎球菌外膜蛋白结合而制成,每针0.5ml菌苗中含15μg多糖。
Children younger than 2 years old who have been infected with influenza type b (Hib) may not develop anti-Hib capsular polysaccharide (PRP) protective antibodies in vivo and are at risk for re-infection. The authors vaccinated children with a history of Hib infection with influenza B conjugate vaccine to evaluate the immunogenicity and safety of the combination vaccine in children. The combined bacterin was made from the combination of b-type influenza bacilli capsular polysaccharide with serogroup B meningococcal outer membrane protein containing 15 μg of polysaccharide per 0.5 ml of vaccine.