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目的研制吡喹酮缓释包埋剂,观察其预防小鼠血吸虫病的效果。方法将吡喹酮原药与控释材料硫化硅橡胶、交联剂和催化剂等按一定比例经一定工艺制成吡喹酮缓释包埋剂,经体外释放试验确定最佳配方剂型,并进行动物实验观察其预防小鼠血吸虫病的效果。结果缓释剂型为棒状,长2cm,外径 2mm,每根含吡喹酮原药30mg。小鼠植入药棒(2根/鼠)后4周进行感染(40尾/鼠),感染后7周解剖观察,其预防保护率为40.2％,肝虫卵减少率64.3％,粪EPG减少率70.5％。结论吡喹酮缓释包埋剂是一种有希望的预防动物感染的新缓释剂型。
Objective To develop praziquantel sustained-release embedding agent and observe its effect on preventing schistosomiasis in mice. Methods The praziquantel sustained-release embedding agent was prepared by a certain proportion of the praziquantel original drug and the controlled release material vulcanized silicone rubber, crosslinking agent and catalyst, and the best formulation was determined by in vitro release test Animal experiments to observe the effect of preventing schistosomiasis in mice. Results sustained-release formulations for the rod-shaped, length 2cm, diameter 2mm, each containing praziquantel 30mg. Four weeks after the implantation of the medicated rod (2 rats / mouse), the mice were infected (40 rats / mouse). Seven weeks after the infection, the prevention rate was 40.2%, the reduction rate of hepatic eggs was 64.3%, and the fecal EPG was decreased Rate of 70.5%. Conclusion Praziquantel slow-release embedding agent is a promising new sustained-release dosage form for preventing animal infection.