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目的:基于99m Tc-HL91作为一种新的缺氧显像剂,体外研究证实整体缺氧心肌对其摄取和潴留增加,来确定99m Tc-H191是否可以探测体内局部缺血心肌。方法:8只成年杂种犬,钳夹冠状动脉左旋支(LCx)。注射185MBq(5mCi)的99m Tc-HL91和微球后4小时内用γ照相机进行系列显像。心脏断
OBJECTIVE: To determine whether 99m Tc-H191 can detect ischemic myocardium in vivo based on 99m Tc-HL91 as a novel hypoxia imaging agent that has been shown to increase uptake and retention by global hypoxic myocardium in vitro. Methods: Eight adult mongrel dogs were used to clamp the left circumflex coronary artery (LCx). Serial imaging with a gamma camera was performed within 4 hours after injection of 185 MBq (5 mCi) of 99m Tc-HL91 and microspheres. Heart broken