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为了进一步研究中药“癌症镇痛散”的安全性 ,进行了家兔皮肤刺激试验、豚鼠皮肤过敏试验、家兔皮肤急性毒性试验和皮肤长期毒性试验。结果显示 ,“癌症镇痛散”外用对家兔皮肤有轻度刺激性 ;大剂量 (2g kg ,6g kg)单次应用也只表现皮肤局部轻度刺激反应 ;大剂量 (3g kg ,8g kg)连续应用 2个月 ,表现出用药局部皮肤增厚、真皮浅层结缔组织轻度增生 ,未见全身毒性反应 ;不能引起豚鼠过敏反应。提示“癌症镇痛散”在临床试用剂量下是基本安全的
In order to further study the safety of Chinese medicine “cancer analgesic powder”, rabbit skin irritation test, guinea pig skin allergy test, rabbit skin acute toxicity test and skin long-term toxicity test were conducted. The results showed that the topical “cancer analgesic powder” had slight irritation to the skin of rabbits; high dose (2g kg, 6g kg) showed only mild local irritation to the skin in a single application; large dose (3g kg, 8g kg ) Continuous application for 2 months showed localized skin thickening, mild superficial connective tissue hyperplasia in the dermis, and no systemic toxicity reaction; no guinea pig allergic reaction. Prompt “cancer analgesia” is basically safe under clinical trial dosage