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抗原单独不能与 T 细胞结合,也不能使其活化。T 细胞识别外来抗原分子是与同时识别自身的MHC Ⅰ类、Ⅱ类基因产物相联系的。免疫学家们长期以来试图阐明这种 MHC 约束的抗原识别的结构基础。过去的几年中已分别证实了 T 细胞抗原受体(Ti)。Ti 分子由α、β异二聚体组成,与 T_3分子一起构成一个复合体,α和β链中含有与 Ig 的 C 和V区同源的功能区,Ti αβ分子决定了 T 细胞的特异性抗原识别和 MHC 的特异性约束作用。将一对αβ基因转染 T 细胞,并在其中表达之,这样,受者T细胞能够对供者 T 细胞识别的抗原和 MHC Ⅱ类
Antigen alone can not bind to T cells, nor can it be activated. T cells recognize foreign antigen molecules are identified simultaneously with their MHC Ⅰ, Ⅱ gene products linked. Immunologists have long sought to elucidate the structural basis of this MHC-constrained antigen recognition. The T cell antigen receptor (Ti) has been confirmed in the past few years, respectively. The Ti molecule consists of α, β heterodimers and forms a complex together with the T_3 molecule. The α and β chains contain functional regions homologous to the C and V regions of Ig, and the Ti αβ molecule determines the specificity of T cells Antigen Recognition and MHC Specific Constraints. A pair of αβ genes are transfected into T cells and expressed therein so that recipient T cells can recognize donor T cells for antigen and MHC class II