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目的 探讨三种药物在高原人体运动中的作用。 方法 对进驻海拔 410 0 m高原 2 0 d的 40名健康青年随机分为红景天组、乙酰唑胺组、西氏胶囊组和食用淀粉组 ,每组 10人。在安静时 ,服药前踏阶运动后及服药后踏阶运动后分别检测血乳酸 (BL A)、肌红蛋白 (Mb)及血氨 (Am mo)含量。 结果 4组青年安静时及服药前踏阶运动后 BL A、Mb及 Amm o组间比较差异均无显著性意义 (P>0 .0 5 ) ;4组服药前踏阶运动后与安静时比较 BL A、Mb、Amm o均增高 (P<0 .0 1) ;服药后踏阶运动后与安静时比较 BL A、Amm o增高 (P<0 .0 1) ,Mb在食用淀粉组、乙酰唑胺组和西氏胶囊组增高 ,差异有显著性意义 (P<0 .0 1或 P<0 .0 5 ) ,红景天组变化无统计学意义 (P>0 .0 5 )。服药 6 d踏阶运动后红景天组、乙酰唑胺组、西氏胶囊组与食用淀粉组比较 BL A、Am mo降低 (P<0 .0 5或 P<0 .0 1) ,Mb在红景天组和乙酰唑胺组降低有显著性意义 (P<0 .0 1或 P<0 .0 5 ) ,西氏胶囊组变化无显著性意义(P>0 .0 5 ) ;红景天组与乙酰唑胺组、西氏胶囊组比较 BL A、Amm o及 Mb降低有显著性意义 (P<0 .0 1或 P<0 .0 5 )。乙酰唑胺组与西氏胶囊组比较三项指标变化均无显著性意义 (P>0 .0 5 )。服药后较服药前红景天组 BL A、Amm o及 Mb均降低 (P<0 .
Objective To explore the role of three drugs in human movement at high altitude. Methods Forty young healthy adults, who were stationed at an altitude of 410 m for 20 days, were randomly divided into Rhodiola group, acetazolamide group, Xishen capsule group and edible starch group, with 10 in each group. The levels of BL A, Mb and Am mo were measured at rest, after taking the first steps and taking the steps after taking the medicine. Results There was no significant difference in the BL A, Mb and Ammo groups between the 4 groups when they were quiet and before the step-taking exercise. (P> 0.05) BL A, Mb and Ammo were all increased (P <0.01). Compared with resting, BL A and Amm o increased (P <0.01) Azole group and Xishi capsule group increased, the difference was significant (P <0.01 or P <0.05), Rhodiola rosea group had no significant change (P> 0.05). The BL A and Am mo were decreased (P <0.05 or P <0.01) in the rhodiola group, acetazolamide group and Xishen capsule group compared with the edible starch group Rhodiola group and acetazolamide decreased significantly (P <0.01 or P <0.05), XZZ capsule group had no significant change (P> 0.05); Rhodiola Compared with acetazolamide group and xishi capsule group, the BL A, Ammo and Mb decreased significantly in the group of day and the group of day (P <0.01 or P <0.05). Acetazolamide group and Cis capsule group compared three indicators had no significant change (P> 0.05). After taking medicine Rhodiola than pretreatment group BL A, Amm o and Mb were lower (P <0.