肿瘤的形成、进展和转移与癌基因、抑癌基因的突变和表达失调有关。Ras是最早发现并确认的人类癌基因,其与肿瘤发生发展的关系一直是分子肿瘤学关注的焦点。RASAL1是近年新发现的一种Ras活性调节基因,可能参与部分肿瘤的发生。现就RASAL1与肿瘤关系的研究进展作一综述。 Tumor formation, progression and metastasis are associated with mutations in oncogenes and tumor suppressor genes and dysregulation of expression. Ras is the earliest discovered and confirmed human oncogene, and its relationship with tumorigenesis has been the focus of molecular oncology. RASAL1 is a recently discovered Ras activity regulator, which may be involved in the development of some tumors. The research progress on the relationship between RASAL1 and tumor is reviewed.