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目的:了解我院抗菌药物致药品不良反应(ADR)发生的特点与规律,并探讨有效的防治措施,为临床安全、合理使用抗菌药物提供参考。方法:收集我院2012-2014年上报国家ADR监测中心的抗菌药物致ADR报告111份,对抗菌药物引发ADR所涉及的患者年龄与性别、给药途径、药品种类以及累及器官/系统和临床表现等进行统计、分析。结果:<10岁患儿和>60岁老年患者ADR发生率最高,分别占27.93%、25.23%;抗菌药物静脉给药途径ADR发生率最高,占84.68%;头孢菌素类药物引发的ADR最多,占26.13%;抗菌药物所致ADR主要累及皮肤及其附件损害,占44.92%。结论:临床药师可以此为切入点向临床医师、护士提供技术支持,防止ADR的重复发生。
Objective: To understand the characteristics and rules of ADR caused by antibacterial drugs in our hospital, and to explore effective prevention and cure measures to provide reference for clinical safety and rational use of antibacterial drugs. Methods: A total of 111 ADR reports were collected from our national ADR surveillance center from 2012 to 2014 in our hospital. The age and sex, route of administration, types of drugs and the organ / systemic and clinical manifestations of patients involved in antimicrobial drug-induced ADR were collected. Such as statistics, analysis. Results: The incidence of ADR was the highest in children <10 years old and> 60 years old, accounting for 27.93% and 25.23% respectively. The incidence of ADR was highest in intravenous antibiotics, accounting for 84.68% of the total. ADR caused by cephalosporins was the most , Accounting for 26.13%; ADR caused by antimicrobial drugs mainly affected the skin and its accessories damage, accounting for 44.92%. Conclusion: Clinical pharmacists can provide clinicians and nurses with technical support as an entry point to prevent the recurrence of ADR.