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目的观察一枝蒿水提物对小鼠胃肠运动的影响,探讨其作用机制。方法将小鼠随机分为正常对照组、多潘立酮组及一枝蒿水提物高、中、低剂量组。灌胃给药5 d后,以葡聚糖蓝2000为标记物,观察色素在5组小鼠胃内的残留比,以及幽门括约肌至色素最前端及至盲肠的距离比。结果一枝蒿高剂量组及多潘立酮组的胃残留率、肠推进率与对照组比较,差异有统计学意义(P<0.05,P<0.01),2组之间差异无统计学意义(P>0.05)。结论一枝蒿水提物能有效改善小鼠的胃肠动力。
Objective To observe the effect of aqueous extract of Artemisia annua on gastrointestinal motility in mice and to explore its mechanism. Methods Mice were randomly divided into normal control group, domperidone group and Artemisia annua L. aqueous extract groups at high, medium and low doses. Five days after intragastric administration, Dextran Blue 2000 was used as a marker to observe the residual ratio of the pigment in the stomach of the 5 groups of mice and the ratio of the distance from the pylorus sphincter to the forefront of the pigment and to the cecum. Results The gastric residual rate and intestinal propulsion rate in high artemisia and domperidone groups were significantly different from those in control group (P <0.05, P <0.01), but there was no significant difference between the two groups (P> 0.05 ). Conclusion Artemisia annua extract can effectively improve gastrointestinal motility in mice.