我院应用三氧化二砷(As2 O3 )注射液(静滴)治疗难治和复发急性早幼粒细胞性白血病(APL)患者12例,现报告如下。1　资料和方法1.1　病例本组复发及难治APL病例均按文献[1] 诊断。其中女性5例,男性7例,平均年龄2 2岁(7～4 4岁) ,复发性APL 4例,在全反式维甲酸(ATRA)治疗达完全缓解 Application of arsenic trioxide (As2 O3) injection (intravenous infusion) in our hospital in the treatment of refractory and relapsed acute promyelocytic leukemia (APL) in 12 patients are as follows. 1 Materials and Methods 1.1 Cases This group of relapsed and refractory APL cases were diagnosed according to the literature [1]. Among them, 5 were women and 7 were males. The mean age was 22 years (range, 7 to 44 years). Four patients had recurrent APL and achieved complete remission in all-trans retinoic acid (ATRA)