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目的:探讨IgA肾病患者,尿内白介素-6(尿IL-6)水平与肾小球、小管间质损伤的相关性。方法:采用酶联免疫吸附法(ELISA)检测本院肾内科50例IgA肾病患者及40例健康对照者尿的IL-6水平,并对IgA肾病组肾小球、小管间质病理损伤进行半定量评分。结果:IgA肾病组尿IL-6水平明显高于健康对照组(P<0.01);IgA肾病患者尿IL-6水平与24h尿蛋白定量(r=0.35,P<0.05)、尿NAG酶/尿Cr(r=0.45,P<0.01)呈正相关,并与肾脏病理中的肾小球慢性病变指数(r=0.32,P<0.05)、肾间质炎症细胞浸润指数(r=0.28,P<0.05)、肾小管萎缩和肾间质纤维化指数(r=0.41,P<0.01)均呈正相关;尿IL-6水平与肾小球毛细血管袢活动性指数无关。结论:尿IL-6水平增高可以反映IgA肾病患者肾小球慢性病变、肾小管间质尤其是近端肾小管的损伤程度,对IgA肾病病情判断有临床意义。
Objective: To investigate the correlation between IgA nephropathy, urinary interleukin-6 (IL-6) and glomerular and tubulointerstitial injury. Methods: Urinary IL-6 level was measured by enzyme-linked immunosorbent assay (ELISA) in 50 patients with IgA nephropathy and 40 healthy controls, and the pathological changes of glomerular and tubulointerstitial were observed in IgA nephropathy group Quantitative rating. Results: The level of urinary IL-6 in IgA nephropathy group was significantly higher than that in healthy control group (P <0.01); urinary IL-6 level in IgA nephropathy group was significantly higher than that in 24 h urinary protein (r = 0.35, Cr (r = 0.45, P <0.01), and were positively correlated with the indexes of glomerular chronic lesion index (r = 0.32, ), Tubular atrophy and renal interstitial fibrosis index (r = 0.41, P <0.01). There was no correlation between urinary IL-6 and glomerular capillary activity index. Conclusion: Increased urinary IL-6 level can reflect the degree of glomerular chronic glomerular lesions and tubulointerstitial damage in IgA nephropathy patients. It is of clinical significance for judging IgA nephropathy.