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目的:观察益血生胶囊联合利血生片治疗慢性乙型肝炎合并白细胞减少症的临床效果。方法:选取医院2015年3月—2016年3月收治的70例慢性乙型肝炎合并白细胞减少症患者,按照随机数字表法分为观察组与对照组,每组35例,对照组服用利血生片治疗,观察组采用益血生胶囊联合利血生片治疗,比较两组患者临床疗效及对慢性乙型肝炎合并白细胞减少症的影响。结果:观察组患者治疗总有效率高达94.29%,较对照组的71.43%明显提高,差异具有统计学意义(P<0.05);观察组的ALT复常例数和复常率、HBV-DNA转阴例数和转阴率显著高于对照组,差异有统计学意义(P<0.05);治疗后观察组患者外周血白细胞计数水平显著高于对照组(P<0.05);两组患者未见明显不良反应。结论:针对慢性乙型肝炎合并白细胞减少症患者,采用益血生胶囊联合利血生片治疗,有利于缓解临床症状,增加外周白细胞计数水平,减轻患者痛苦,不良反应少,安全可靠性高,具有较高的临床应用价值。
Objective: To observe the clinical effects of Yishensheng Capsule combined with Reserpine on chronic hepatitis B with leucopenia. Methods: Seventy patients with chronic hepatitis B and leucopenia admitted from March 2015 to March 2016 in our hospital were divided into observation group and control group according to the random number table method, with 35 cases in each group. The control group was given reserpine The observation group was treated with Yisheng Sheng Capsule combined with Reserpine, and the clinical efficacy and the effect on chronic hepatitis B with leucopenia were compared between the two groups. Results: The total effective rate of observation group was 94.29%, which was significantly higher than that of control group (71.43%), the difference was statistically significant (P <0.05). The ALT normalization rate and normalization rate, The number of cases and the rate of negative conversion were significantly higher than that of the control group (P <0.05). The level of peripheral blood leukocyte count in the observation group was significantly higher than that in the control group (P <0.05) Adverse reactions. Conclusion: The treatment of chronic hepatitis B patients with leucopenia, the use of Yisheng Health Capsule combined with reserpine treatment, help to alleviate clinical symptoms and increase peripheral leukocyte count, reduce patient pain, fewer adverse reactions, high safety and reliability, Has a high clinical value.